Key result
Myosin-ATP reaction kinetics reveal a muscle contraction mechanism driven by cyclic phosphorylation and conformational changes.
Population
In vitro myosin and actomyosin preparations
Design
Preclinical
Authors
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Hypothesis-generating for actomyosin mechanics; leaves open translation to human muscle physiology or disease.
This basic science study details the pre-steady state kinetics of the myosin-ATP system, proposing that muscle contraction is driven by myosin conformational changes coupled with cyclic phosphorylation and dephosphorylation.
Tonomura et al. (1969) studied this question. ATP and ATP analogues was evaluated on Reaction mechanism of the myosin-ATP system. A molecular mechanism of muscle contraction was proposed involving conformational changes of myosin coupled with cyclic phosphorylation and dephosphorylation.
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