Key result
Transient kinetic studies of Mg2+-dependent ATPase of myosin subfragment 1 from rabbit skeletal muscle support a seven-step mechanism involving reversible cleavage of bound ATP.
Population
Myosin subfragment 1 prepared from rabbit skeletal muscle
Design
Preclinical
Authors
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May inform actomyosin kinetic models; leaves open translation to cardiac muscle and clinical relevance.
The study elucidates a seven-step mechanism for the myosin ATPase reaction, highlighting reversible ATP cleavage and extensive oxygen exchange with water.
Bagshaw et al. (1975) studied this question. Transient kinetic and isotopic tracer studies was evaluated on Mechanism of Mg2+-dependent adenosine triphosphatase of myosin subfragment 1. Transient kinetic studies of Mg2+-dependent ATPase of myosin subfragment 1 from rabbit skeletal muscle support a seven-step mechanism involving reversible cleavage of bound ATP.
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