Population
Myosin subfragment 1 active site (in vitro biochemical model)
Design
Preclinical
Authors
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Reversible ATP cleavage at myosin extends cross-bridge models; leaves open translation to human cardiac therapies.
This basic science study demonstrates that ATP cleavage in the myosin active site is readily reversible and suggests the beta-phosphate of ADP is highly constrained.
Geeves et al. (1980) studied this question.
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