Why the study?
Does sibutramine added to verapamil/trandolapril improve blood pressure and heart rate in obese hypertensive patients?
Population
54 obese hypertensive patients receiving a low-fat low-calorie diet
Comparison
Sibutramine 10 mg together with verapamil… vs Open-label verapamil sustained…
Design
RCT, randomly allocated, open-label
Follow-up
6 months
Authors
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Supports adjunctive sibutramine for greater diastolic BP reduction in obese hypertension on verapamil/trandolapril; extends RCT evidence of hemodynamic safety.
Does sibutramine added to verapamil/trandolapril improve blood pressure and heart rate in obese hypertensive patients?
Adding sibutramine to verapamil/trandolapril in obese hypertensive patients safely reduces diastolic blood pressure and improves metabolic profiles without increasing heart rate.
Nakou et al. (2008) studied this question.
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