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July 1, 1956Circulation ResearchOpen Access

The Aortic Flow Pulse as Related to Differential Pressure

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Population

Dogs (preclinical model)

Comparison

Measurement of aortic flow pulse using a… vs Previously published curves and simultaneously…

Design

Preclinical

Authors

MSMerrill P. SpencerSwedish Medical CenterADADAM B. DENISONAtrium Health Wake Forest Baptist

Discussion

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Implication

Challenges resistance-centric aortic flow models in animals; leaves open translation to human hemodynamics and clinical relevance.

Key Points

  • Investigate the contour of flow pulsations in the descending aorta and determine their physical relationship to differential pressure pulses.
  • Recorded flow pulsations in canine descending aortas using a noncannulating square-wave electromagnetic flowmeter.
  • Assessed flowmeter validity by testing instrument adequacy and comparing flow waves with simultaneously measured differential pressures.
  • Recorded descending aortic flow pulsations differed substantially from previously published contour curves.
  • Inertia dominated over resistance in generating the aortic flow pulse, demonstrating that blood flow relates to differential pressure primarily via fluid acceleration.

Structured PICO

P
Population
Dogs (preclinical model)
I
Intervention
Measurement of aortic flow pulse using a noncannulating square wave electromagnetic flowmeter
C
Comparator
Previously published curves and simultaneously recorded differential pressures
O
Outcome
Aortic flow pulse characteristics and relationship to differential pressuresurrogate

This preclinical study demonstrates that inertia, rather than resistance, is the dominant factor in the genesis of the aortic flow pulse.

Cite This Study

Spencer et al. (1956) studied this question.

synapsesocial.com/papers/6a87292ef87adc0a02ca31f2https://doi.org/10.1161/01.res.4.4.476
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Dynamics of Pulsatile Blood Flow1954 · 69 citations
  2. 2A Square Wave Electromagnetic Flowmeter for Application to Intact Blood Vessels1955 · 98 citations
  3. 3A Newly Modified Electromagnetic Blood Flowmeter Capable of High Fidelity Flow Registration1952 · 28 citations