Smooth muscle gelsolin and a Ca2+‐sensitive contractile cell model

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Population

Human lung fibroblast MRC-5 cells permeabilized with Triton X-100 and smooth muscle gelsolin purified from…

Design

Preclinical

Authors

Discussion

Gelsolin effects on contractility remain preclinical; leaves open any role in cardiac fibrosis or remodeling.

Population

Human lung fibroblast MRC-5 cells permeabilized with Triton X-100 (MRC-5 cell models) and smooth muscle gelsolin purified from bovine aorta

Intervention

Purified smooth muscle gelsolin and Ca2+ ionophore A23187

Outcome

Cell contractility and destruction of stress fiberssurrogate

Smooth muscle gelsolin disrupts stress fibers and inhibits cell contraction in a Ca2+-dependent manner in MRC-5 cell models.

Kanno et al. (1989) studied this question.

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