Why the study?
Is parental history of cardiovascular disease mortality associated with higher Lp(a) levels in adult offspring with familial hyperlipidemia?
Is parental history of cardiovascular disease mortality associated with higher Lp(a) levels in adult offspring with familial hyperlipidemia?
In families with hyperlipidemia, elevated Lp(a) levels in adult offspring are strongly associated with maternal, but not paternal, history of cardiovascular disease mortality.
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Maternal CVD mortality may flag higher Lp(a) in hyperlipidemic offspring; hypothesis-generating and requires prospective validation before clinical use.
Kim et al. (2001) studied this question.
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