Why the study?
Do VKORC1 and CYP2C9 variants influence the mean weekly warfarin dose required to reach therapeutic INR in Italian patients?
Do VKORC1 and CYP2C9 variants influence the mean weekly warfarin dose required to reach therapeutic INR in Italian patients?
Genetic variants in VKORC1 and CYP2C9 significantly influence warfarin dose requirements, explaining up to 56% of variability when combined with age and weight.
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VKORC1/CYP2C9 variants may inform initial warfarin dosing in Italians; hypothesis-generating pending randomized outcome trials.
Borgiani et al. (2007) studied this question.
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