July 1, 2005HeartOpen Access

PAI-1 and homocysteine, but not lipoprotein (a) and thrombophilic polymorphisms, are independently associated with the occurrence of major adverse cardiac events after successful coronary stenting

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Why the study?

Are specific thrombophilic polymorphisms, PAI-1, homocysteine, and Lp(a) associated with the occurrence of MACE in patients with acute coronary syndromes after coronary stenting?

Population

520 patients with acute coronary syndromes who underwent coronary stenting, and 520 age and sex matched…

Design

Cohort

Authors

RMRossella MarcucciInterventional Cardiology

Discussion

Member takes

Implication

May aid post-stenting risk stratification in ACS; leaves open whether modifying these levels reduces MACE.

Structured PICO

Are specific thrombophilic polymorphisms, PAI-1, homocysteine, and Lp(a) associated with the occurrence of MACE in patients with acute coronary syndromes after coronary stenting?

Population

520 patients (375 men and 145 women) with acute coronary syndromes who underwent coronary stenting, and 520 age and sex matched controls.

Intervention

Evaluation of factor V Leiden, prothrombin G20210A polymorphism, PAI-1 4G/5G polymorphism, PAI-1, homocysteine, and lipoprotein (a) (Lp(a)) concentrations

Outcome

Occurrence of major adverse cardiac events (MACE)composite

Increased PAI-1 and homocysteine concentrations are independent risk factors for major adverse cardiac events after successful coronary stenting in patients with acute coronary syndromes.

Cite This Study

Rossella Marcucci (2005) studied this question.

synapsesocial.com/papers/6a8797b972575bdad0e9c987 https://doi.org/10.1136/hrt.2005.061895

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Bookmark

PAI-1 and homocysteine, but not lipoprotein (a) and thrombophilic polymorphisms, are independently associated with the occurrence of major adverse cardiac events after successful coronary stenting

Discussion

Member takes

Implication

Structured PICO

Cite This Study

PAI-1 and homocysteine, but not lipoprotein (a) and thrombophilic polymorphisms, are independently associated with the occurrence of major adverse cardiac events after successful coronary stenting

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider