Why the study?
Does intravenous fentanyl reduce ticagrelor absorption and platelet inhibition in cardiac patients undergoing PCI?
Population
212 cardiac patients undergoing coronary angiography, of which 70 required percutaneous coronary…
Comparison
Intravenous fentanyl, in addition to local… vs No fentanyl, in addition to local anaesthetic…
Design
RCT, randomized
Follow-up
24 hours
Authors
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May warrant avoiding fentanyl with ticagrelor loading in PCI; extends opioid-P2Y12 interaction evidence to this agent.
Does intravenous fentanyl reduce ticagrelor absorption and platelet inhibition in cardiac patients undergoing PCI?
Fentanyl administration impairs ticagrelor absorption and delays platelet inhibition during PCI, leading to mild excess myocardial damage and suggesting a class-wide opioid interaction.
Shah et al. (2018) studied this question.
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