Population
Mice with targeted disruption of both nfatc3 and nfatc4 genes (nfatc3-/-nfatc4-/- embryos)
Comparison
Cardiac-specific expression of constitutively… vs nfatc3-/-nfatc4-/- embryos without the rescue…
Design
Preclinical
Authors
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NFATc3/4 findings in mice are hypothesis-generating; leaves open relevance to human cardiac metabolism or congenital disease.
NFATc3 and NFATc4 are essential for embryonic heart development, as their loss causes mitochondrial metabolic failure and embryonic lethality, which can be partially rescued by cardiac-specific NFATc4 expression.
Bushdid et al. (2003) studied this question.
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