February 1, 1996AJP Heart and Circulatory Physiology

Relationship between structural and hemodynamic heterogeneity in microvascular networks

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Population

Microvascular network in the rat mesentery consisting of 913 segments

Comparison

Topological and geometric idealization of the… vs Observed heterogeneous network structure

Design

Preclinical

Authors

APAxel R. PriesCross-Cutting Cardiology TSTimothy W. SecombCross-Cutting Cardiology PGP. GaehtgensCalifornia Institute of Technology

Discussion

Member takes

Implication

Microvascular models must incorporate both heterogeneities; leaves open translation to human physiology.

Structured PICO

Population

Microvascular network in the rat mesentery consisting of 913 segments

Intervention

Topological and geometric idealization of the network structure (symmetric topology and equal lengths/diameters)

Comparator

Observed heterogeneous network structure

Outcome

Network hemodynamics including overall network conductance, pressure distribution, mean capillary hematocrit, and dispersion of arteriovenous transit timesurrogate

Accurate description of microvascular hemodynamics requires accounting for both topological and geometric structural variability.

Cite This Study

Pries et al. (1996) studied this question.

synapsesocial.com/papers/6a879a6ae94369e4287d6692 https://doi.org/10.1152/ajpheart.1996.270.2.h545

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Relationship between structural and hemodynamic heterogeneity in microvascular networks

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Relationship between structural and hemodynamic heterogeneity in microvascular networks

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider