Thrombolytic therapy for embolic MI in the setting of unsuspected infective endocarditis can lead to fatal cerebral hemorrhage.
May warrant endocarditis screening before thrombolysis in embolic MI; hypothesis-generating for safer reperfusion strategies.
Cerebral hemorrhage occurs in 0.2% of patients under the age of 60 years treated with thrombolytic therapy for acute myocardial infarction. A case of fatal cerebral hemorrhage following TPA therapy for myocardial infarction due to probable coronary artery embolism during unsuspected native valve infective endocarditis is reported.
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Salvo et al. (1994) studied this question.
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