Why the study?
Does losartan or spironolactone prevent synthetic androgen-induced cardiac autonomic dysfunction and ventricular repolarization disturbances in rats?
Population
30 male Wistar rats
Comparison
Losartan (20 mg kg daily) or spironolactone (20… vs Sedentary, trained, nandrolone…
Design
Preclinical
Follow-up
8 weeks
Authors
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RAAS inhibition counters androgen-induced autonomic and repolarization changes in rats; leaves open human translation.
Does losartan or spironolactone prevent synthetic androgen-induced cardiac autonomic dysfunction and ventricular repolarization disturbances in rats?
Inhibiting the renin-angiotensin-aldosterone system with losartan or spironolactone prevents cardiac parasympathetic dysfunction and ventricular repolarization disturbances induced by chronic high-dose synthetic androgens in rats.
Neto et al. (2012) studied this question.
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