Why the study?
High doses of synthetic anabolic androgenic steroids can cause serious negative cardiovascular effects, but their combined effects with exercise training on ventricular repolarization and cardiac autonomic modulation remained to be evaluated.
Does endurance exercise training prevent ventricular repolarization abnormalities and cardiac autonomic dysfunction induced by high-dose nandrolone decanoate in rats?
Population
Male Wistar rats
Comparison
Sedentary vehicle vs sedentary nandrolone decanoate vs swimming vehicle vs swimming nandrolone decanoate
Design
Animal study
Key result
Combining an endurance swimming training protocol with 8 weeks of nandrolone decanoate treatment attenuated ventricular repolarization abnormalities but did not prevent cardiac autonomic dysfunction.
Authors
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Endurance training offers incomplete protection vs. nandrolone cardiotoxicity in rats; leaves open human translation and mechanisms.
Does endurance exercise training prevent ventricular repolarization abnormalities and cardiac autonomic dysfunction induced by high-dose nandrolone decanoate in rats?
Endurance exercise training attenuates ventricular repolarization abnormalities but fails to prevent cardiac autonomic dysfunction induced by high-dose anabolic steroids in rats.
Marocolo et al. (2019) studied this question. Nandrolone decanoate and swimming training vs. Vehicle (peanut oil with benzyl alcohol) and sedentary behavior was evaluated on Ventricular repolarization (QT interval and QT dispersion) and cardiac autonomic modulation (heart rate variability). Combining an endurance swimming training protocol with 8 weeks of nandrolone decanoate treatment attenuated ventricular repolarization abnormalities but did not prevent cardiac autonomic dysfunction.
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