Key result
Combining an endurance swimming training protocol with 8 weeks of nandrolone decanoate treatment attenuated ventricular repolarization abnormalities but did not prevent cardiac autonomic dysfunction.
Why the study?
High doses of synthetic anabolic androgenic steroids can cause serious negative cardiovascular effects, but their combined effects with exercise training on ventricular repolarization and cardiac autonomic modulation remained to be evaluated.
Does endurance exercise training prevent ventricular repolarization abnormalities and cardiac autonomic dysfunction induced by high-dose nandrolone decanoate in rats?
Does endurance exercise training prevent ventricular repolarization abnormalities and cardiac autonomic dysfunction induced by high-dose nandrolone decanoate in rats?
Endurance exercise training attenuates ventricular repolarization abnormalities but fails to prevent cardiac autonomic dysfunction induced by high-dose anabolic steroids in rats.
Answers are grounded in this paper and cite their sources.
Endurance training offers incomplete protection vs. nandrolone cardiotoxicity in rats; leaves open human translation and mechanisms.
Several studies have reported that high doses of synthetic anabolic androgenic steroids (AAS) can have serious negative effects on health, including the cardiovascular system. The aim of this study was to evaluate the combined effects of AAS and exercise training on ventricular repolarization and cardiac autonomic modulation in rats. Male Wistar rats were allocated into 4 groups: sedentary rats treated with vehicle, sedentary rats treated with nandrolone decanoate, swimming-trained rats treated with vehicle, and swimming-trained rats treated with nandrolone decanoate. Ventricular repolarization was evaluated by electrocardiographic analysis of QT interval and QT dispersion. Cardiac autonomic modulation was assessed by heart rate variability. Our results show that AAS increased QT interval and QT dispersion in sedentary rats treated with nandrolone decanoate as compared to sedentary rats treated with vehicle, indicating AAS-induced ventricular repolarization abnormalities. When rats treated with nandrolone decanoate were subjected to concomitant exercise training, ventricular repolarization was normalized. On the other hand, AAS-induced reduction in cardiac parasympathetic modulation was not prevented by exercise training. In conclusion, AAS produced cardiac autonomic dysfunction and ventricular repolarization disturbances in rats. Combining an exercise training protocol during the AAS treatment attenuated the ventricular repolarization abnormalities and did not prevent cardiac autonomic dysfunction.
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Marocolo et al. (2019) studied this question. Nandrolone decanoate and swimming training vs. Vehicle (peanut oil with benzyl alcohol) and sedentary behavior was evaluated on Ventricular repolarization (QT interval and QT dispersion) and cardiac autonomic modulation (heart rate variability). Combining an endurance swimming training protocol with 8 weeks of nandrolone decanoate treatment attenuated ventricular repolarization abnormalities but did not prevent cardiac autonomic dysfunction.
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