Why the study?
Does the combination of anabolic steroids and endurance exercise alter cardiac contractile function in male Sprague-Dawley rats?
Population
52 male Sprague-Dawley rats
Comparison
Anabolic steroid combined with endurance… vs Sedentary control, steroid-treated alone, or…
Design
Preclinical, randomly assigned
Follow-up
10 weeks
Key result
Anabolic steroid treatment combined with endurance exercise significantly depressed cardiac contractile function compared to exercise or steroid treatment alone (p<0.05).
Authors
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Combination may impair rat cardiac contractile function; leaves open relevance to human athletes or clinical use.
RCT (n=52)
Randomly assigned
Does the combination of anabolic steroids and endurance exercise alter cardiac contractile function in male Sprague-Dawley rats?
p-value: p=<0.05
The combination of anabolic steroid treatment and endurance exercise produces a depressive effect on cardiac contractile function in a rat model, whereas neither intervention alone alters function.
Liang et al. (1993) conducted an RCT in Cardiac performance (n=52). Anabolic steroids (Nandrolone decanoate) and endurance exercise vs. Sedentary control, steroid alone, or exercise alone was evaluated on In vitro cardiac contractile function (Left ventricular +dP/dt, dP/dt at 60 mmHg developed pressure, tension time index, and Emax) (p=<0.05). Anabolic steroid treatment combined with endurance exercise significantly depressed cardiac contractile function compared to exercise or steroid treatment alone (p<0.05).
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