Why the study?
Does the combination of anabolic steroids and exercise impair cardiac microvascular adaptation compared to exercise alone in mice?
Population
Female SPF-NMRI mice
Comparison
Anabolic steroids combined with exercise or… vs Sedentary control and exercise alone
Design
Preclinical
Follow-up
3 and 6 weeks
Key result
Anabolic steroids combined with exercise impaired exercise-induced increases in cardiac capillary density at 6 weeks (4,076 vs 5,411 capillaries/mm2 for exercise alone; p<0.05).
Authors
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May compromise myocardial perfusion in steroid-using athletes; hypothesis-generating from animal data and requires human validation.
Does the combination of anabolic steroids and exercise impair cardiac microvascular adaptation compared to exercise alone in mice?
Absolute Event Rate: 4076% vs 5411%
p-value: p=< 0.05
Anabolic steroids combined with exercise induce mild cardiac myocyte hypertrophy but impair exercise-induced microvascular adaptation, potentially compromising myocardial oxygen supply.
Tagarakis et al. (2000) studied this question. Anabolic steroids (Dianabol or Oral-Turinabol) + exercise vs. Exercise alone or sedentary control was evaluated on Capillary density at 6 weeks (capillaries/mm2) (p=< 0.05). Anabolic steroids combined with exercise impaired exercise-induced increases in cardiac capillary density at 6 weeks (4,076 vs 5,411 capillaries/mm2 for exercise alone; p<0.05).
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