Key result
Supraphysiological doses of anabolic androgenic steroids were associated with smaller left ventricular dimensions, thicker walls, impaired diastolic function, and myocardial degeneration.
Why the study?
Do supraphysiological doses of anabolic androgenic steroids cause structural and functional alterations in the heart in athletes and experimental animals?
Population
25 human males and 30 adult albino rats
Comparison
Supraphysiological doses of anabolic androgenic… vs Non-using bodybuilders and nonathletic controls…
Design
Other
Follow-up
8 weeks (for rat model)
Authors
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Supports cardiac monitoring in AAS users; leaves open need for prospective validation before practice change.
Cross-Sectional (n=55)
Do supraphysiological doses of anabolic androgenic steroids cause structural and functional alterations in the heart in athletes and experimental animals?
Supraphysiological doses of anabolic androgenic steroids cause significant structural and functional myocardial damage, with strain rate imaging showing promise for early detection of systolic dysfunction in athletes.
Hassan et al. (2009) conducted a cross-sectional in Anabolic androgenic steroid use (n=55). Anabolic androgenic steroids (AAS) vs. Bodybuilders not using steroids, nonathletic males, and control rats was evaluated on Structural and functional alterations in the heart (echocardiographic, histological, and ultrastructural changes). Supraphysiological doses of anabolic androgenic steroids were associated with smaller left ventricular dimensions, thicker walls, impaired diastolic function, and myocardial degeneration.
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