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February 1, 2000Journal of Applied Physiology

Androgenic steroid administration produced a further rightward shift in the LVED P-D relationship and reduced LVED h/r to control values, without altering LV collagen.

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Why the study?

Does chronic administration of an androgenic steroid alter exercise-induced left ventricular remodeling in rats?

Population

Rats undergoing habitual exercise on voluntary running wheels

Comparison

Chronic administration of a high-dose androgenic… vs Exercised rats not receiving the steroid (control)

Design

Preclinical

Authors

AWAngela J. WoodiwissBTB. TrifunovicMPM. Philippides

Discussion

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Overview

High-dose androgens may blunt exercise-induced LV remodeling benefits in rats; leaves open human relevance.

Structured PICO

Does chronic administration of an androgenic steroid alter exercise-induced left ventricular remodeling in rats?

P
Population
Rats undergoing habitual exercise on voluntary running wheels
I
Intervention
Chronic administration of a high-dose androgenic steroid
C
Comparator
Exercised rats not receiving the steroid (control)
O
Outcome
Left ventricular end diastolic (LVED) pressure-volume or internal dimension (P-D) relationships and relative wall thickness (h/r)surrogate

High-dose androgenic steroid administration alters exercise-induced LV remodeling in rats, reducing the beneficial effect of physiological LV hypertrophy on relative wall thickness.

Cite This Study

Woodiwiss et al. (2000) studied this question.

synapsesocial.com/papers/6a7886fdd3a6aa87c6be4e6chttps://doi.org/10.1152/jappl.2000.88.2.409
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Anabolic Steroids and Endurance Exercise on Cardiac Performance1993 · 20 citations
  2. 2Anabolic steroids induce cardiac renin-angiotensin system and impair the beneficial effects of aerobic training in rats2007 · 123 citations
  3. 3Left ventricular size and function in body builders using anabolic steroids1985 · 68 citations
  4. 4Androgen and glucocorticoid mechanisms in exercise-induced cardiac hypertrophy1984 · 17 citations
  5. 5Sex Differences in Morphological and Functional Aspects of Exercise-Induced Cardiac Hypertrophy in a Rat Model2019 · 32 citations