March 29, 2011Medicine & Science in Sports & ExerciseOpen Access

Anabolic Steroid Associated to Physical Training Induces Deleterious Cardiac Effects

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Structured PICO

Population

Male Wistar rats, n=112 (8 groups of 14)

Intervention

Nandrolone decanoate (10 mg/kg/wk) with or without swimming training (5 times per week) for 10 weeks, and with or without losartan (20 mg/kg/d) or spironolactone (10 mg/kg/d) in drinking water

Comparator

Control group (no nandrolone decanoate, no training, no losartan or spironolactone)

Outcome

Cardiac hypertrophy and fibrosis (collagen volumetric fraction and cardiac collagen type III expression)surrogate

Pharmacological blockade of AT1 or mineralocorticoid receptors prevents cardiac hypertrophy and fibrosis induced by nandrolone decanoate and physical training in rats, suggesting a key role for cardiac aldosterone.

Discussion

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Implication

Supports aldosterone/AT1 blockade against steroid cardiotoxicity in rats; hypothesis-generating with human translation untested.

Cite This Study

Carmo et al. (2011) studied this question.

synapsesocial.com/papers/6a8d19ad03141e7fb3906647 https://doi.org/10.1249/mss.0b013e318217e8b6

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Anabolic Steroid Associated to Physical Training Induces Deleterious Cardiac Effects

Structured PICO

Discussion

Implication

Cite This Study

Anabolic Steroid Associated to Physical Training Induces Deleterious Cardiac Effects

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider