Why the study?
Do BK channel modulators affect cell viability under hyperkalemia or hypokalemia conditions in HEK293 cells expressing the hslo subunit?
Population
HEK293 cells expressing the hslo subunit (hslo-HEK293) and wild-type HEK293 cells
Comparison
BK channel openers and blockers under… vs Absence of BK channel modulators
Design
Preclinical
Follow-up
24 h
Authors
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Does not support clinical use of BK modulators; leaves open their role in potassium homeostasis for further study.
Do BK channel modulators affect cell viability under hyperkalemia or hypokalemia conditions in HEK293 cells expressing the hslo subunit?
BK channel openers prevent hyperkalemia-induced cell proliferation in HEK293 cells expressing the hslo subunit, suggesting a role for BK channels in regulating cell viability during abnormal potassium homeostasis.
Tricarico et al. (2013) studied this question.
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