Key result
BK channel modulators such as TEA and tetrandrine significantly altered osteoblast cell numbers, and TEA increased mineralization in primary osteoblasts.
Population
MG63 cells and primary human osteoblasts
Comparison
BK channel modulators including… vs Absence of BK channel modulators
Design
Preclinical
Authors
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BK channel modulation affects osteoblast function in animal models; leaves open therapeutic relevance for human bone disease.
The BK channel in human osteoblasts has a distinctive pharmacology and its modulation affects cell proliferation and mineralization, suggesting a potential therapeutic target for bone.
Henney et al. (2009) studied this question. BK channel modulators (TEA, tetrandrine, iberiotoxin, paxilline, isopimaric acid) vs. Absence of modulators was evaluated on Cell numbers and mineralization. BK channel modulators such as TEA and tetrandrine significantly altered osteoblast cell numbers, and TEA increased mineralization in primary osteoblasts.
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