February 4, 1965New England Journal of Medicine
Hemolytic Anemia Complicating Aortic-Valve Surgery
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Discussion
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Implication
Case series reveals acquired hemolytic anemia with positive serology after aortic-valve surgery, suggesting an autoimmune rather than purely mechanical mechanism.
Key Points
- To describe the clinical presentation of acquired hemolytic anemia following aortic-valve surgery and evaluate a potential autoimmune mechanism.
- Clinical evaluation and serologic testing of patients presenting with acquired hemolytic anemia after undergoing aortic-valve surgery (N=7).
- Identified 7 cases of post-surgical hemolytic anemia characterized by positive serologic tests and clinical patterns inconsistent with solely mechanical red cell destruction.
- The clinical and serologic profile suggests an unrecognized post-cardiac surgery syndrome mediated by an autoimmune hemolytic process.
Cite This Study
Pirofsky et al. (1965) studied this question.