Key result
Insertion of a rigid lucite ball valve resulted in hemolytic anemia due to mechanical trauma to red cells, which was substantially decreased when an elastic silicone valve was used.
Why the study?
Does an elastic silicone valve reduce red-cell destruction compared to a rigid lucite ball valve in dogs?
Population
Dogs with prosthetic materials inserted between the apex of the left ventricle and the thoracic aorta
Comparison
Elastic silicone valve with a resilient housing vs Rigid lucite ball valve
Design
Other
Authors
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Elastic valves may reduce hemolysis in prosthetic models; leaves open translation to human valve design.
Does an elastic silicone valve reduce red-cell destruction compared to a rigid lucite ball valve in dogs?
Mechanical trauma from rigid prosthetic valves can cause hemolytic anemia, which may be mitigated by using more resilient materials.
DeCesare et al. (1965) studied Hemolytic anemia. Lucite ball valve vs. Elastic silicone valve was evaluated on Red-cell destruction. Insertion of a rigid lucite ball valve resulted in hemolytic anemia due to mechanical trauma to red cells, which was substantially decreased when an elastic silicone valve was used.