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February 1, 1996Acta Paediatrica

Physiological anticoagulants and activated protein C resistance in childhood stroke

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Why the study?

Are hereditary deficiencies in physiological anticoagulants and activated protein C resistance present in patients with childhood stroke?

Population

24 patients with stroke in childhood, along with healthy controls of younger age

Comparison

Measurement of immunological and functional… vs Healthy controls of younger age

Design

Case-control

Authors

RRRS RiikonenKuopio University HospitalEVEM VahteraFinnish Red CrossRKRM KekomäkiFinnish Red Cross

Discussion

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Implication

No deficiencies found in this small cohort; leaves open the value of thrombophilia screening and need for larger studies before changing diagnostic criteria.

Structured PICO

Are hereditary deficiencies in physiological anticoagulants and activated protein C resistance present in patients with childhood stroke?

P
Population
24 patients with stroke in childhood, along with healthy controls of younger age
I
Intervention
Measurement of immunological and functional protein S, protein C and antithrombin III levels and anticoagulant responses to activated protein C
C
Comparator
Healthy controls of younger age
O
Outcome
Presence of hereditary deficiencies of physiological anticoagulantssurrogate

Hereditary deficiencies of physiological anticoagulants were not identified in this cohort of childhood stroke, emphasizing the need for careful diagnostic criteria to avoid inappropriate treatment.

Cite This Study

Riikonen et al. (1996) studied this question.

synapsesocial.com/papers/6a87bd96350e059174ad2ca8https://doi.org/10.1111/j.1651-2227.1996.tb14002.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Recurrent Venous Thromboembolism in Patients with a Partial Deficiency of Protein S1984 · 510 citations
  2. 2An abnormal plasma distribution of protein S occurs in functional protein S deficiency1986 · 285 citations
  3. 3Hereditary and Acquired Risk Factors for Childhood Stroke1994 · 73 citations
  4. 4Acquired protein S deficiency.1993 · 1 citations
  5. 5Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.1993 · 1,986 citations