Why the study?
Observational studies link adiposity to liver fat and NAFLD, which associate with T2D and CAD, but causal factors remain unexplored.
Does genetically predicted abdominal adiposity (waist circumference) causally increase the risk of non-alcoholic fatty liver disease, type 2 diabetes, and coronary artery disease?
Does genetically predicted abdominal adiposity (waist circumference) causally increase the risk of non-alcoholic fatty liver disease, type 2 diabetes, and coronary artery disease?
Abdominal adiposity, measured by waist circumference, is an independent causal factor for NAFLD, type 2 diabetes, and coronary artery disease, highlighting the importance of assessing body fat distribution.
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Abdominal adiposity may independently drive NAFLD and cardiometabolic risk beyond BMI; leaves open whether routine waist measurement should guide prevention.
Gagnon et al. (2022) studied this question.
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