October 1, 1994European Heart Journal
Haemostatic factors and prevalent coronary heart disease; the FINRISK haemostasis study
Why the study?
Are haemostatic factors associated with prevalent coronary heart disease in adults aged 45-64 years?
Population
2365 participants aged 45-64 years from the population-based FINRISK Haemostasis Study, including 88 men and…
Comparison
High levels of haemostatic factors (fibrinogen… vs Participants without prevalent CHD
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Lp(a) and fibrinogen associations with prevalent CHD in men require prospective confirmation; should not yet inform clinical risk assessment.
Structured PICO
Are haemostatic factors associated with prevalent coronary heart disease in adults aged 45-64 years?
P
Population
2365 participants aged 45-64 years from the population-based FINRISK Haemostasis Study, including 88 men and 44 women with prevalent coronary heart disease (CHD).
I
Intervention
High levels of haemostatic factors (fibrinogen, lipoprotein (a), factor VII antigen, factor VII activity, plasminogen) and non-HDL cholesterol
C
Comparator
Participants without prevalent CHD
O
Outcome
Prevalent coronary heart disease (CHD)
High levels of lipoprotein (a), fibrinogen, and non-HDL cholesterol are associated with prevalent coronary heart disease, with significant interactions between these factors.
Limitations
- Cross-sectional design cannot prove causality
Cite This Study
Salomaa et al. (1994) studied this question.