Why the study?
Does prednisone alter digital vascular reactivity to L-norepinephrine in normotensive and hypertensive subjects?
Population
Normotensive subjects and patients with essential hypertension
Comparison
Oral prednisone 30 mg daily for 1 or 3 weeks, or… vs Baseline (before administration)
Design
Other
Follow-up
3 weeks
Authors
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May enhance NE reactivity in normotensives but not essential hypertensives; hypothesis-generating for differential vascular effects pending confirmation.
Does prednisone alter digital vascular reactivity to L-norepinephrine in normotensive and hypertensive subjects?
Glucocorticosteroids increase digital vascular reactivity to norepinephrine in normotensive individuals but not in those with essential hypertension.
Mendlowitz et al. (1961) studied this question.
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