October 1, 1998Planta Medica
Myocardial Protective Effect of an Anthraquinone-Containing Extract ofPolygonum multiflorumEx Vivo
Why the study?
Does pretreatment with an anthraquinone-containing extract of Polygonum multiflorum reduce myocardial ischemia-reperfusion injury in isolated perfused rat hearts?
Population
Isolated perfused rat hearts (ex vivo model of myocardial ischemia-reperfusion injury)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating in isolated rat hearts; leaves open clinical translation of Polygonum multiflorum anthraquinones for ischemia-reperfusion injury.
Structured PICO
Does pretreatment with an anthraquinone-containing extract of Polygonum multiflorum reduce myocardial ischemia-reperfusion injury in isolated perfused rat hearts?
P
Population
Isolated perfused rat hearts (ex vivo model of myocardial ischemia-reperfusion injury)
I
Intervention
Pretreatment with Polygonum multiflorum Thunb. (PME) extract, its anthraquinone-containing fraction (PME-I), alpha-tocopherol acetate (VE), or emodin (EMD)
O
Outcome
Myocardial ischemia-reperfusion injury assessed by LDH leakage and contractile force recoverysurrogate
An anthraquinone-containing extract of Polygonum multiflorum protects against myocardial ischemia-reperfusion injury ex vivo by sustaining glutathione antioxidant status.
Cite This Study
Yim et al. (1998) studied this question.