Why the study?
Does ligation of coronary artery branches cause changes in the electrocardiogram in dogs?
Does ligation of coronary artery branches cause changes in the electrocardiogram in dogs?
This preclinical study describes the electrocardiographic, anatomic, and pathologic changes following experimental coronary artery ligation in a canine model.
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Caution against extrapolating canine ligation ECG changes to patients; extends preclinical models but leaves human translation open.
This article is based on a study of sixty-six dogs in which known myocardial lesions had been produced by the ligation of definite branches of the coronary arteries of the heart. While the experiments were made with the primary object of determining the change in the electrocardiograms brought about by these ligations, other results, anatomic and pathologic, are deemed worthy of brief mention.
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FRED M. SMITH (2004) studied this question.
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