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May 1, 1995Nephrology Dialysis Transplantation

Risks of acute renal failure after cardiopulmonary bypass surgery in children: a retrospective 10-year case-control study

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Why the study?

What are the risk factors for acute renal failure following cardiopulmonary bypass surgery in children?

Population

234 children selected from a cohort of 2262 children undergoing cardiopulmonary bypass surgery from 1982 to…

Comparison

Hemodynamic alterations and inotrope use vs Children who did not develop acute renal…

Design

Case-control

Authors

SPStefano PiccaFPF. PrincipatoEMEnnio Mazzera

Discussion

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Overview

May warrant heightened monitoring for hemodynamic instability in pediatric CPB; leaves open whether targeted interventions reduce ARF.

Structured PICO

What are the risk factors for acute renal failure following cardiopulmonary bypass surgery in children?

P
Population
234 children (58 cases, 176 matched controls) selected from a cohort of 2262 children undergoing cardiopulmonary bypass surgery from 1982 to 1991. Cases developed acute renal failure requiring peritoneal dialysis. Median age of cases 8.5 months.
I
Intervention
Hemodynamic alterations and inotrope use (central venous hypertension >12 h, systolic arterial hypotension >12 h, dopamine >15 μg/kg/min, adrenaline, isoproterenol)
C
Comparator
Children who did not develop acute renal failure, matched for age, cardiopulmonary bypass and circulatory arrest duration, and year of operation
O
Outcome
Acute renal failure requiring peritoneal dialysishard clinical

Hemodynamic alterations and high-dose inotrope use are major risk factors for acute renal failure following cardiopulmonary bypass surgery in children, which is associated with high mortality.

Cite This Study

Picca et al. (1995) studied this question.

synapsesocial.com/papers/6a87c2fcf455bdf6826c8656https://doi.org/10.1093/ndt/10.5.630
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiopulmonary bypass management and acute renal failure: risk factors and prognosis2008 · 88 citations
  2. 2Risk Factors for Development of Acute Renal Failure (ARF) Requiring Dialysis in Patients Undergoing Cardiac Surgery1998 · 147 citations
  3. 3Acute Renal Failure in Children Undergoing Cardiopulmonary Bypass2005 · 29 citations
  4. 4Impact of cardiopulmonary bypass management on postcardiac surgery renal function2002 · 149 citations
  5. 5Cardiopulmonary Bypass and Renal Injury2006 · 102 citations