What question did this study set out to answer?

To re-evaluate the species-specific interactions and cross-reactivity between tissue thromboplastin (tissue factor) and blood plasma across commonly utilized experimental animal models.

April 21, 2009Haemostasis

Species Specificity of Tissue Thromboplastin

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Authors

TJT.L. JansonUniversity of Oslo HSHelge StormorkenOslo University Hospital HPHans PrydzOslo University Hospital

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Implication

Comparative laboratory study demonstrates distinct reactivity between thromboplastin and plasma across experimental animal species, highlighting critical considerations for clotting assay design.

Key Points

To re-evaluate the species-specific interactions and cross-reactivity between tissue thromboplastin (tissue factor) and blood plasma across commonly utilized experimental animal models.
Tested all pairwise combinations of tissue thromboplastin and plasma obtained from several standard experimental animal species in comparative in vitro clotting assays.
Thromboplastin exhibits marked species specificity, altering clotting dynamics when paired with non-homologous animal plasma.
Coagulation kinetics depend heavily on the specific donor species combination, underscoring the requirement for homologous or validated cross-reactive reagents in clotting experiments.

Cite This Study

Janson et al. (2009) studied this question.

synapsesocial.com/papers/6a87c3a6ba4ee383afbb53a5 https://doi.org/10.1159/000215102

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Implication

Comparative laboratory study demonstrates distinct reactivity between thromboplastin and plasma across experimental animal species, highlighting critical considerations for clotting assay design.

Species Specificity of Tissue Thromboplastin

Discussion

Member takes

Implication

Key Points

Cite This Study

Species Specificity of Tissue Thromboplastin

Discussion

Member takes

Implication

Key Points

Cite This Study

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