Why the study?
Does progressive reduction of arterial pressure affect arterial and venous vascular resistance in isolated dog hind limbs?
Population
30 isolated dog hind limbs, autoperfused from the contralateral femoral artery
Comparison
Progressive reduction of arterial pressure from… vs Baseline or higher arterial pressure levels
Design
Preclinical
Authors
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No direct clinical implications in humans; leaves open hypoxia as a driver of peripheral autoregulation.
Does progressive reduction of arterial pressure affect arterial and venous vascular resistance in isolated dog hind limbs?
Autoregulation of blood flow in the dog hind limb may be partly due to tissue hypoxia rather than the tissue pressure hypothesis, as arterial resistance decreases with reduced arterial pressure.
Hanson et al. (1962) studied this question.
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