Why the study?
Does increasing perfusion pressure alter critical pressure and arterial resistance in the canine hindlimb?
Population
Anesthetized dogs (pump-perfused vascularly isolated hindlimbs)
Comparison
Increasing perfusion pressure from 75 to 175… vs Baseline perfusion pressure / normal carotid…
Design
Preclinical
Authors
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Informs animal vascular physiology models; extends concepts of pressure-dependent resistance but leaves open human translation.
Does increasing perfusion pressure alter critical pressure and arterial resistance in the canine hindlimb?
Increasing perfusion pressure causes the arterial vasculature to constrict at the level of the Starling resistor and dilate more proximally in the canine hindlimb.
Shrier et al. (1993) studied this question.