Why the study?
Does maximal vasodilation with adenosine and nitroprusside eliminate the vascular waterfall (Pcrit) in canine hindlimbs?
Population
Pump perfused vascularly isolated canine hindlimbs
Comparison
Maximal vasodilation with adenosine and… vs Before vasodilation (control values)
Design
Preclinical
Authors
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Residual Pcrit after maximal vasodilation does not affect canine hindlimb flow; leaves open relevance to human microcirculation.
Does maximal vasodilation with adenosine and nitroprusside eliminate the vascular waterfall (Pcrit) in canine hindlimbs?
A small arteriolar critical pressure remains present during maximal vasodilation in canine hindlimbs but is lower than downstream pressure and does not affect flow.
Shrier et al. (1995) studied this question.
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