Why the study?
Does nifedipine infusion decrease waterfall pressure and arterial resistance in pump perfused canine hindlimbs?
Population
Pump perfused canine hindlimbs
Comparison
Infusion of the calcium channel blocker nifedipine vs Control conditions (before nifedipine infusion)
Design
Preclinical
Authors
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May inform preclinical vascular models; leaves open translation to human therapy.
Does nifedipine infusion decrease waterfall pressure and arterial resistance in pump perfused canine hindlimbs?
In a canine hindlimb model, nifedipine decreases waterfall pressure, arterial resistance, and venous resistance, while increasing regional elastic recoil pressure at constant perfusion pressure.
Shrier et al. (1995) studied this question.
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