Population
Canine hindlimb model
Comparison
NG-nitro-L-arginine infusion or phenylephrine… vs Control conditions (before infusion)
Design
Preclinical
Authors
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Similar responses to phenylephrine suggest nonspecific vasoconstriction; leaves open EDRF-specific effects on limb hemodynamics in vivo.
Blocking EDRF synthesis with L-NNA increases waterfall pressure and upstream resistance in the canine hindlimb, similar to the effects of phenylephrine.
Shrier et al. (1995) studied this question.
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