What question did this study set out to answer?

To examine transient and reactive hyperaemia responses to abrupt arterial pressure changes and evaluate resistance microvessel stretching in the resting canine hindlimb.

April 1, 1984Clinical and Experimental Pharmacology and Physiology

Transient Pressure‐flow Responses in the Resting Canine Hindlimb ‐ Analysis as Responses to Rapid Stretching of the Resistance Microvessels

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Authors

AGA. H. GoodmanThe University of Sydney RERosemarie EinsteinThe University of Sydney

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Implication

Physiological study demonstrates microvessel distension after sudden pressure rises in canine hindlimbs, indicating that vessel distensibility drops as active wall tension increases.

Key Points

To examine transient and reactive hyperaemia responses to abrupt arterial pressure changes and evaluate resistance microvessel stretching in the resting canine hindlimb.
Perfused the resting hindlimbs of anaesthetized, areflexic dogs across steady-state pressures ranging from 50 to 150 mmHg.
Measured flow changes following sudden pressure elevation and arterial occlusion durations of 3, 5, 10, 20, and 40 seconds.
Applied experimental data to a mathematical model of an idealized resistance vessel to construct vascular distensibility curves.
Transient flow increases showed a linear relationship with pressure changes for both sudden pressure steps and reactive hyperaemia, independent of steady-state perfusion pressure.
Reactive hyperaemia flow responses decreased with shorter occlusion times, demonstrating dependence on both vessel relaxation and the magnitude of the pressure restoration step.
Mathematical modeling indicated that microvascular distensibility decreased as active wall tension increased under higher steady-state pressures.

Cite This Study

Goodman et al. (1984) studied this question.

synapsesocial.com/papers/6a87c52ee6314279fbfb0b8b https://doi.org/10.1111/j.1440-1681.1984.tb00248.x

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Implication

Physiological study demonstrates microvessel distension after sudden pressure rises in canine hindlimbs, indicating that vessel distensibility drops as active wall tension increases.

Transient Pressure‐flow Responses in the Resting Canine Hindlimb ‐ Analysis as Responses to Rapid Stretching of the Resistance Microvessels

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Implication

Key Points

Cite This Study

Transient Pressure‐flow Responses in the Resting Canine Hindlimb ‐ Analysis as Responses to Rapid Stretching of the Resistance Microvessels

Discussion

Member takes

Implication

Key Points

Cite This Study

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