Why the study?
Do acetylcholine, substance P, and VIP influence endogenous noradrenaline overflow and vasoconstriction in canine blood perfused gracilis muscle compared to other vasodilators?
Do acetylcholine, substance P, and VIP influence endogenous noradrenaline overflow and vasoconstriction in canine blood perfused gracilis muscle compared to other vasodilators?
Prejunctional muscarinic inhibition of noradrenaline release by acetylcholine occurs in skeletal muscle in vivo, whereas other vasodilators do not influence sympathetic neurotransmission.
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Acetylcholine inhibits noradrenaline release in canine skeletal muscle in vivo; extends prior in vitro data but remains hypothesis-generating without clinical implications.
Kahan et al. (1985) studied this question.
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