Why the study?
Does a loading dose of ticagrelor compared to prasugrel achieve optimal platelet reactivity inhibition at different times in NSTE ACS patients undergoing PCI?
Population
24 consecutive patients undergoing percutaneous coronary intervention for non-ST-elevation acute coronary…
Comparison
Loading dose of ticagrelor vs Loading dose of prasugrel
Design
RCT, randomised
Follow-up
24 hours
Authors
Loading...
Supports rapid P2Y12 inhibition with either agent pre-PCI; confirms comparable onset in NSTE-ACS.
Does a loading dose of ticagrelor compared to prasugrel achieve optimal platelet reactivity inhibition at different times in NSTE ACS patients undergoing PCI?
In NSTE ACS patients undergoing PCI, a loading dose of either ticagrelor or prasugrel provides optimal P2Y12 receptor blockade within 2 hours and maximal inhibition within 4 hours.
Laine et al. (2015) studied this question.
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