Answers are grounded in this paper and cite their sources.
Review summarizes mechanisms of impaired compensatory angiogenesis in systemic sclerosis, highlighting pathways that prevent vascular repair.
Systemic sclerosis is a chronic autoimmune connective tissue disease characterized by vascular injury and fibrosis and by an impaired angiogenesis which cannot ensure an efficient vascular recovery. Vascular injury is responsible for hypoxia and tissual ischemia which are the primary triggers for angiogenesis and are not able to induce a compensatory angiogenesis. This review article is focused on current knowledge on the mechanisms responsible for angiogenesis dysregulation in systemic sclerosis.
No takes yet. Share an insight, caveat, or question.
Cantatore et al. (2017) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: