Population
Mice, rhesus monkeys, and in vitro models using human rhinovirus 14 and seven additional rhino/enteroviruses
Design
Preclinical
Authors
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Fluorine substitution may optimize oral exposure of benzimidazoles in mice; leaves open human antiviral translation and requires clinical studies.
Fluorine substitution on the left-hand aromatic ring of vinylacetylene benzimidazoles optimizes in vitro antirhino/enteroviral activity and oral bioavailability in mice.
Tebbe et al. (1997) studied this question.
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