What question did this study set out to answer?

To review the morphological, molecular, and clinical evidence supporting tumour budding as an additional prognostic parameter in colorectal cancer management.

April 24, 2012British Journal of CancerOpen Access

Tumour budding: a promising parameter in colorectal cancer

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Authors

ALAlessandro LugliUniversity of Bern EKEva KaramitopoulouPrograms for Assessment of Technology in Health Research Institute IZInti ZlobecUniversity of Bern

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Implication

Narrative review shows strong prognostic value of tumour budding in colorectal cancer, suggesting its inclusion alongside standard staging systems.

Key Points

To review the morphological, molecular, and clinical evidence supporting tumour budding as an additional prognostic parameter in colorectal cancer management.
Reviewed published guidelines, historical classification systems, and international staging literature regarding colorectal cancer prognostic factors.
Assessed morphological, molecular, and prognostic findings from multiple international studies evaluating tumour budding and tumor-border configuration.
Current TNM staging insufficiently distinguishes high-risk stage II patients who experience outcomes similar to stage III patients and might benefit from adjuvant chemotherapy.
Dozens of worldwide study groups confirmed the consistent prognostic significance of tumour budding despite variations in study designs and assessment methodologies.
Tumour budding and tumor-border configuration remain underreported in routine histopathology relative to established morphological scoring systems used in other cancers.

Cite This Study

Lugli et al. (2012) studied this question.

synapsesocial.com/papers/6a87cfdf24ca9e5e63015be3 https://doi.org/10.1038/bjc.2012.127

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Implication

Narrative review shows strong prognostic value of tumour budding in colorectal cancer, suggesting its inclusion alongside standard staging systems.

Tumour budding: a promising parameter in colorectal cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Tumour budding: a promising parameter in colorectal cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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