May 12, 2005Journal of Virology

5′-Terminal Deletions Occur in Coxsackievirus B3 during Replication in Murine Hearts and Cardiac Myocyte Cultures and Correlate with Encapsidation of Negative-Strand Viral RNA

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Structured PICO

Population

Adult murine cardiomyocytes, mice inoculated with CVB3, and HeLa cell cultures

Intervention

Infection or transfection with coxsackievirus B3 (CVB3) or CVB3 cDNA clones with 5'-terminal deletions (CVB3/TD)

Comparator

Parental CVB3 virions

Outcome

Viral replication, cytopathicity, and genomic alterations (5'-terminal deletions)surrogate

Naturally occurring 5'-terminal deletions in the coxsackievirus B3 genome are associated with the generation of noncytolytic virus and long-term viral persistence in the heart.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May underlie persistent CVB3 infection in myocarditis; hypothesis-generating and requires human validation before clinical relevance.

Cite This Study

Tracy et al. (2005) studied this question.

synapsesocial.com/papers/6a87d26f3f31f6b699bb63b6 https://doi.org/10.1128/jvi.79.11.7024-7041.2005

Topics

Myocarditis

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5′-Terminal Deletions Occur in Coxsackievirus B3 during Replication in Murine Hearts and Cardiac Myocyte Cultures and Correlate with Encapsidation of Negative-Strand Viral RNA

Structured PICO

Discussion

Implication

Cite This Study

Topics

5′-Terminal Deletions Occur in Coxsackievirus B3 during Replication in Murine Hearts and Cardiac Myocyte Cultures and Correlate with Encapsidation of Negative-Strand Viral RNA

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider