Key result
Deep sequencing of cardiac biopsies from a patient with dilated cardiomyopathy revealed a major proportion (84.8%) of 5' terminally deleted coxsackievirus B3 populations.
Case Report (n=1)
No
The study demonstrates the existence of major 5' terminally deleted coxsackievirus B3 populations in endomyocardial tissues of a patient with idiopathic dilated cardiomyopathy, suggesting a mechanism for viral persistence.
May support viral persistence mechanism in idiopathic DCM; hypothesis-generating case report requiring larger validation.
We performed deep sequencing analysis of the enterovirus 5' noncoding region in cardiac biopsies from a patient with dilated cardiomyopathy. Results displayed a mix of deleted and full-length coxsackievirus B3, characterized by a low viral RNA load (8.10(2) copies/μg of nucleic acids) and a low viral RNA positive-sense to RNA negative-sense ratio of 4.8.
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Bouin et al. (2016) conducted a case report in Idiopathic dilated cardiomyopathy (n=1). Coxsackievirus B3 infection was evaluated on Proportion of 5' terminally deleted coxsackievirus B3 populations. Deep sequencing of cardiac biopsies from a patient with dilated cardiomyopathy revealed a major proportion (84.8%) of 5' terminally deleted coxsackievirus B3 populations.
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