Why the study?
Does a virus-specific cDNA hybridisation probe detect persistent coxsackie B virus RNA in endomyocardial biopsies of patients with dilated cardiomyopathy and myocarditis?
Population
n=38 total; 27 patients with histopathological evidence of active or healed myocarditis or dilated…
Comparison
Virus-specific cDNA hybridisation probe applied… vs Endomyocardial biopsies from patients with…
Design
Case-control
Authors
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Should not yet change myocarditis or DCM management; extends evidence for persistent coxsackie B etiology but remains hypothesis-generating.
Does a virus-specific cDNA hybridisation probe detect persistent coxsackie B virus RNA in endomyocardial biopsies of patients with dilated cardiomyopathy and myocarditis?
The detection of coxsackie B virus RNA in over half of the patients with myocarditis or dilated cardiomyopathy supports a persistent viral etiology in these conditions.
Archard et al. (1987) studied this question.
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