Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system
Population
Cell-free system from human HeLa cells
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Poly(A) tail augments picornavirus IRES translation in vitro; leaves open extension to cellular or in vivo infection models.
Structured PICO
P
Population
Cell-free system from human HeLa cells
I
Intervention
Addition of poly(A) tail to picornaviral RNAs (poliovirus, encephalomyocarditis virus, and hepatitis A virus)
O
Outcome
Translation efficiency/stimulationsurrogate
The poly(A) tail significantly augments cap-independent translation driven by picornavirus IRESes in a mammalian cell-free system.
Cite This Study
Bergamini et al. (2000) studied this question.