Why the study?
Does caffeine prevent digitalis-induced ventricular tachyarrhythmias in isolated guinea pig hearts?
Population
Isolated guinea pig hearts perfused by means of a modified Langendorff apparatus
Comparison
Caffeine combined with digitalis… vs Digitalis alone, caffeine alone, and control
Design
Preclinical
Authors
Loading...
Caffeine may suppress digitalis-induced tachyarrhythmias in this model; leaves open whether sarcoplasmic reticulum calcium release inhibition informs clinical antiarrhythmic strategies.
Does caffeine prevent digitalis-induced ventricular tachyarrhythmias in isolated guinea pig hearts?
In an isolated guinea pig heart model, caffeine abolished digitalis-induced ventricular tachyarrhythmias, supporting the role of sarcoplasmic reticulum calcium release in their pathogenesis.
Valle et al. (1983) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: