Population
Endothelial cells derived from circulating progenitors outgrown from human umbilical cord blood, and mature…
Comparison
Inhibition of EPDC-associated uPA by monoclonal… vs Untreated EPDC and mature endothelial cells
Design
Preclinical
Authors
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uPA/uPAR inhibition attenuates EPDC angiogenesis in animal models; hypothesis-generating for human vascular repair, pending prospective studies.
Endothelial progenitor cells possess high intrinsic uPA/uPAR-dependent proteolytic activity that contributes to their invasive and angiogenic behavior, highlighting a potential mechanism for vascular repair.
Basire et al. (2006) studied this question.
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