Population
Purified cell fractions (neutrophils, platelets, monocytes) and whole blood models
Comparison
Activation with phorbol 12-myristate 13-acetate… vs Resting/unstimulated cells or selective platelet…
Design
Preclinical
Follow-up
up to 90 minutes (in vitro)
Authors
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Neutrophil activation may selectively disrupt platelet conjugates; leaves open differential leukocyte roles in human thrombosis.
Neutrophil activation decreases the expression of the ligand for platelet P-selectin, leading to the inhibition of neutrophil-platelet adhesion and dissociation of existing conjugates.
Rinder et al. (1994) studied this question.
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